The molecular and functional characterization of E2F-5 transcription factor.

  title={The molecular and functional characterization of E2F-5 transcription factor.},
  author={Yash Vaishnav and M Y Vaishnav and Vinod Pant},
  journal={Biochemical and biophysical research communications},
  volume={242 3},
The E2F activity plays a critical role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. We describe here molecular cloning and functional characterization of a fifth member of the E2F family of transcription factors. E2F-5 protein is more homologous to E2F-4 (72% amino acid identity) than to E2F-1, E2F-2, and E2F-3 (35% amino acid identity). Based on structural and functional criteria, the E2F… CONTINUE READING


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