The modulatory effect of pyrethroids on acetylcholine release in the hippocampus of freely moving rats.

@article{Hossain2004TheME,
  title={The modulatory effect of pyrethroids on acetylcholine release in the hippocampus of freely moving rats.},
  author={Muhammad Mubarak Hossain and Tadahiko Suzuki and Itaru Sato and Tadashi Takewaki and Koichi Suzuki and Haruo Kobayashi},
  journal={Neurotoxicology},
  year={2004},
  volume={25 5},
  pages={825-33}
}
The peripheral effects of pyrethroids on Na(+) channels are well known but the effects on CNS neurotransmission are less known. In the present study, type I and II pyrethroids were found to affect the release of acetylcholine (ACh) from hippocampus in freely moving rats as measured by in vivo microdialysis. The basal release of ACh from the hippocampus of untreated rats was 6.6 pmol/10 microl/10 min. Allethrin had an interesting dual effect on ACh release, increasing ACh efflux (to about 300… CONTINUE READING
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