The modulation of the endocannabinoid system in the treatment of cancer and other systemic human diseases

@inproceedings{Lissoni2018TheMO,
  title={The modulation of the endocannabinoid system in the treatment of cancer and other systemic human diseases},
  author={Paolo Lissoni and Giusy Messina and Giorgio L. Porro and Roberto Trampetti and Arianna Lissoni and Franco Rovelli and Vezika Cenay and Enrica Porta and Giuseppe Di Fede},
  year={2018}
}
It is known that the endocannabinoid system exerts a fundamental role in the regulation of most biological functions by inducing metabolic, immunomodulatory and psychochemical effects, and in particular it has been shown that brain cannabinoid system plays an essential role in both pleasure perception and pain control [1]. Moreover, the recent discoveries in the area of the Psycho-neuro-endocrino-immunology (PNEI) have demonstrated that immune system-mediated systemic human diseases, including… 

SunText Review of Pediatric Care

TLDR
The most frequent systemic disease-associated endocrine alteration is represented by an increased adrenal activity concomitantly to a decline in the pineal function, with the following evidence of high cortisol levels in association with a diminished secretion of melatonin (MLT), the main pineal hormone.

A Randomized Study of High-Dose Pineal Hormone Melatonin Alone Versus High-Dose Melatonin Plus Low-Dose Angiotensin-(1-7) in Untreatable Advanced Cancer Patients

TLDR
The cannabinoid agonists may counteract cancer growth by either exerting a cytotoxic anticancer and anti-angiogenic actions or inhibiting IL-17 secretion, which in contrast stimulates cancer cell proliferation and macrophage release of inflammatory suppressive cytokines, including IL-1beta, IL-6 and TNF-alpha.

Coronavirus-induced severe acute respiratory syndrome (sars) as a possibile expression of fatty acid amide hydrolase (faah) hyper-activation and possible therapeutic role of faah inhibitors in covid19

  • P. Lissoni
  • Biology
    Journal of Clinical Research and Reports
  • 2020
TLDR
COVID 19-related cannabinoid reduced activity would be due to a virus-induced activation of the enzyme responsible for cannabinoid degradation, the fatty acid amide hydrolase (FAAH), and FAAH inhibitors could exert a therapeutic role in COVID 19 infection.

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