The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem.

@article{Jia2009TheMO,
  title={The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem.},
  author={Fan Jia and Peter A Goldstein and Neil L. Harrison},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={328 3},
  pages={1000-6}
}
Eszopiclone (Lunesta; Sepracor, Marlborough, MA) and zolpidem [N,N,6-trimethyl-2-(4-methylphenyl)-imidazo(1,2-a)pyridine-3-acetamide] are among the most commonly prescribed hypnotics in use in the United States. The thalamus plays a pivotal role in sleep regulation and rhythmicity. Two distinct subtypes of synaptic GABA(A) receptors (GABA(A)-Rs), alpha(1)beta(2)gamma(2) and alpha(3)beta(3)gamma(2), are expressed in thalamocortical relay neurons and in interneurons of the RTN (reticular thalamic… CONTINUE READING

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