The modulation of head-twitch behaviour by drugs acting on beta-adrenoceptors: evidence for the involvement of both beta1- and beta2-adrenoceptors

  title={The modulation of head-twitch behaviour by drugs acting on beta-adrenoceptors: evidence for the involvement of both beta1- and beta2-adrenoceptors},
  author={Sheila L. Handley and Lakhbir Singh},
Drugs selective for either the beta1- or beta2-adrenoceptor have been investigated for their effects on the head-twitch behaviour induced by l-5-hydroxytryptophan (l-5-HTP) in mice. All four agonists, dobutamine and prenalterol (beta1-), and salbutamol and procaterol (beta2-), potentiated the effect of l-5-HTP although they were ineffective in inducing the head-twitch when administered alone. The corresponding antagonists, practolol and metoprolol (beta1-) and butoxamine and ICI 118,551 (beta2… 
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