The modulation of DNA content: proximate causes and ultimate consequences.

  title={The modulation of DNA content: proximate causes and ultimate consequences.},
  author={T. Ryan Gregory and Paul D. N. Hebert},
  journal={Genome research},
  volume={9 4},
The forces responsible for modulating the large-scale features of the genome remain one of the most difficult issues confronting evolutionary biology. Although diversity in chromosomal architecture, nucleotide composition, and genome size has been well documented, there is little understanding of either the evolutionary origins or impact of much of this variation. The 80,000-fold divergence in genome sizes among eukaryotes represents perhaps the greatest challenge for genomic holists. Although… 

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