The modular nature of apoptotic signaling proteins

  title={The modular nature of apoptotic signaling proteins},
  author={K. -Th. Hofmann},
  journal={Cellular and Molecular Life Sciences CMLS},
Apoptosis, initiated by a variety of stimuli, is a physiological process that engages a well-ordered signaling cascade, eventually leading to the controlled death of the cell. The most extensively studied apoptotic stimulus is the binding of death receptors related to CD95 (Fas/Apo1) by their respective ligands. During the last years, a considerable number of proteins have been identified which act together in the receptor-proximal part of the signaling pathway. Based on localized regions of… CONTINUE READING
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