The modular mechanism of chromocenter formation in Drosophila

  title={The modular mechanism of chromocenter formation in Drosophila},
  author={Madhav Jagannathan and Ryan Cummings and Y. Yamashita},
  • Madhav Jagannathan, Ryan Cummings, Y. Yamashita
  • Published 2019
  • Biology, Medicine
  • eLife
  • A central principle underlying the ubiquity and abundance of pericentromeric satellite DNA repeats in eukaryotes has remained poorly understood. Previously we proposed that the interchromosomal clustering of satellite DNAs into nuclear structures known as chromocenters ensures encapsulation of all chromosomes into a single nucleus (Jagannathan et al., 2018). Chromocenter disruption led to micronuclei formation, resulting in cell death. Here we show that chromocenter formation is mediated by a… CONTINUE READING
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