The modular architecture of meningococcal factor H-binding protein.

  title={The modular architecture of meningococcal factor H-binding protein.},
  author={Peter T Beernink and Dan M Granoff},
  volume={155 Pt 9},
Meningococcal factor H binding protein (fHbp) is a promising vaccine antigen that binds the human complement downregulatory molecule factor H (fH), and this binding enhances the survival of the organism in serum. Based on sequence variability of the entire protein, fHbp has been divided into three variant groups or two subfamilies. Here, we present evidence based on phylogenetic analysis of 70 unique fHbp amino acid sequences that the molecular architecture is modular. From sequences of natural… CONTINUE READING
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