The modular architecture of bacterial response regulators. Insights into the activation mechanism of the BvgA transactivator of Bordetella pertussis.

@article{Boucher1994TheMA,
  title={The modular architecture of bacterial response regulators. Insights into the activation mechanism of the BvgA transactivator of Bordetella pertussis.},
  author={Philip E. Boucher and Franco Menozzi and Camille Locht},
  journal={Journal of molecular biology},
  year={1994},
  volume={241 3},
  pages={
          363-77
        }
}
Control of virulence factor expression in Bordetella pertussis is mediated by the products of the bvg operon. The BvgS membrane protein responds to certain environmental cues by activating the BvgA protein, which in turn modulates the expression of the target virulence factor genes. The BvgA and BvgS proteins are members of a large family of sensory transduction proteins called the two-component systems. We show that BvgA fusion proteins can activate transcription of a reporter gene containing… CONTINUE READING
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