The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review.

@article{Hanai2011TheMO,
  title={The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review.},
  author={Hiroyuki Hanai and Yuri Takeda and M Eberhardson and Rudolf Gruber and Abby R. Saniabadi and Ola Winqvist and Robert Lofberg},
  journal={Clinical and experimental immunology},
  year={2011},
  volume={163 1},
  pages={50-8}
}
Patients with active inflammatory bowel disease (IBD) have elevated and activated myeloid leucocytes which infiltrate the colonic mucosa in vast numbers. Myeloid leucocytes such as the CD14(+) CD16(+) monocytes are major sources of tumour necrosis factor (TNF)-α, and therefore selective granulocyte/monocyte (GM) adsorption (GMA) should promote remission or enhance efficacy of pharmacological therapy. However, studies in IBD have reported both impressive as well as disappointing efficacy… CONTINUE READING
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