The mode of action of treatment by IgG of haemolytic anaemia induced by an anti-erythrocyte monoclonal antibody.

@article{Pottier1996TheMO,
  title={The mode of action of treatment by IgG of haemolytic anaemia induced by an anti-erythrocyte monoclonal antibody.},
  author={Yves Pottier and I. Pierard and Andrew Hastings Barclay and Pierre Lucien Masson and J P Coutelier},
  journal={Clinical and experimental immunology},
  year={1996},
  volume={106 1},
  pages={
          103-7
        }
}
In order to gain insight into the mechanisms by which the infusion of IgG can improve some autoimmune diseases, we induced haemolytic anaemia in mice by the injection of anti-erythrocyte MoAbs derived from NZB mice by S. Izui (Geneva). The IgG1 antibody 31-9D induces anaemia by erythrocyte sequestration in the spleen and liver, whereas the IgG2a antibody 34-3C triggers erythrophagocytosis (Shibata et al., Int Immunol 1990. 2:1133). Treatment of mice with pools of either human or mouse IgG… CONTINUE READING
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