The mode of action of migraine triggers: a hypothesis.

  title={The mode of action of migraine triggers: a hypothesis.},
  author={G. A. Lambert and Alessandro Stefano Zagami},
  volume={49 2},
OBJECTIVES To review conjectured modes of action of migraine triggers and to present a new hypothesis about them. BACKGROUND Migraine attacks are initiated in many migraineurs by a variety of "triggers," although in some patients no external trigger can be identified. Many triggers provoke attacks with such a short latency that only some kind of neural mechanism can explain the triggering. RESULTS We present here a hypothesis that the pain of migraine has its ultimate origin in the cortex… CONTINUE READING


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