The mode of action of homocysteine on mouse brain glutamic decarboxylase and gamma-aminobutyrate aminotransferase.

In the belief that homocysteine-induced convulsions might be related to alterations in brain gamma-aminobutyric acid metabolism, we have studied the action of this amino acid on the activity of glutamic decarboxylase (GAD, EC and gamma-aminobutyrate aminotransferase (EC of mouse brain in vitro DL-homocysteine competitively inhibited GAD… CONTINUE READING