The mobilization of intracellular cadmium by alkoxyethyl esters of meso-2,3-dimercaptosuccinic acid.

  title={The mobilization of intracellular cadmium by alkoxyethyl esters of meso-2,3-dimercaptosuccinic acid.},
  author={M. Jones and P. K. Singh and G. Gale and L. M. Atkins and A. Smith},
  journal={Toxicology and applied pharmacology},
  volume={106 3},
The cadmium mobilizing properties of two newly synthesized esters of meso-2,3-dimercaptosuccinic acid in mice have been examined. They are: di(2'-methoxyethyl) meso-2,3-dimercaptosuccinate ([-CH(SH)COOCH2CH2OR]2, R = CH3; MEDMS), and di(2'-ethoxyethyl) meso-2,3-dimercaptosuccinate ([-CH(SH)COOCH2CH2OR]2, R = CH2CH3; EEDMS), conveniently prepared from dimercaptosuccinate acid with 2-methoxyethanol and 2-ethoxyethanol, respectively. Mobilization studies in mice of aged in vivo cadmium deposits… Expand
3 Citations
Cadmium mobilization by monoaralkyl- and monoalkyl esters of meso-2,3-dimercaptosuccinic acid and by a dithiocarbamate.
The manner in which the later injections removed smaller fractions of the total body cadmium is consistent with a bodily distribution of these compounds by which they are concentrated primarily in the kidneys and the liver, with much smaller amounts reaching other organs. Expand
meso-2,3-dimercaptosuccinic acid monoalkyl esters: effects on mercury levels in mice.
Determination of the comparative dose-response relationships of DMSA and Mi-ADMS on corporal and renal mercury concentrations revealed the monoester to be more active than DMSA on both parameters at each dose used, which was in good agreement with the values calculated from the excretion data. Expand
Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid in the mouse.
The monoisoamyl ester was the most effective in removing cadmium from both the liver and the kidneys when given orally and is the first compound which is reported capable of mobilizing Cadmium in vivo from aged deposits after oral administration. Expand


The mobilization of intracellular cadmium by butyl and amyl esters of meso-2,3-dimercaptosuccinic acid.
An analysis of the manner in which mobilizing efficacy changes with structure indicates that higher, purely alkyl analogs are not expected to be superior to these compounds, though other structural variations may be. Expand
Esters of meso-dimercaptosuccinic acid as cadmium-mobilizing agents.
All except the dimethyl ester were significantly more effective than BAL in reducing total cadmium body burdens in mice and a synergistic effect was found in the reduction of whole body and kidney Cadmium burdens when Di-PDMS was used in combination with trisodium calcium diethylenethriaminepentaacetate. Expand
N-(2,3-dimercaptopropyl)phthalamidic acid: protection, in vivo and in vitro, against arsenic intoxication.
The effectiveness of DMPA in reducing the toxicity of NaAsO2 was further demonstrated by its reversal of the sodium arsenite inhibition of pyruvate dehydrogenase multienzyme complex (PDH) activity in vitro. Expand
Influence of chelating agents on the distribution and excretion of cadmium in rats.
Gel chromatographic studies of the distribution of Cd among the proteins of the liver cytosol in treated and untreated animals indicate that neither DTPA nor Puchel was able to release Cd from the metallothionein complex. Expand
Determination and metabolism of dithiol chelating agents. VIII. Metal complexes of meso-dimercaptosuccinic acid.
Metal complexes of meso-dimercaptosuccinic acid (DMSA) with Pb2+, Cd2+, and Hg2+ were studied by potentiometric and infrared methods and diMe-meso-DMSA, when given to rats 3 days after Cd administration, greatly increased the excretion of Cd via bile. Expand
In vivo screening of potential antidotes for chronic cadmium intoxication.
Only 2,3-dimercaptopropanol (BAL) and sodium diethyldithiocarbamate (NaDDTC) were able to produce a statistically significant (at the 95% level) reduction in the cadmium content of the kidney. Expand
Mobilization of aged in vivo cadmium deposits by diethyl dimercaptosuccinate.
Diethyl dimercaptosuccinate (DEDMS) was prepared and found to be capable of mobilizing cadmium from mice one month after they had been given an injection (i.p.) of 0.03 mg CdCl2.2.5H2O containing 1.0Expand
The effect of repeated administration of several chelators on the distribution and excretion of cadmium.
The observed increase in urinary excretion of Cd when certain chelators were administered after the induction of hepatic metallothionein suggests that increasing the duration of chelation therapy may decrease the concentrations ofCd in tissues and hence, reduce the toxicity of the metal. Expand
Comparative effects of diethyldithiocarbamate, dimercaptosuccinate, and diethylenetriaminepentaacetate on organ distribution and excretion of cadmium.
It was concluded that the effectiveness of a chelator in promoting mobilization and excretion of metallothionein-bound Cd cannot be predicted on the basis of its effectiveness in protecting mice against a lethal dose of Cd when given immediately after Cd and prior to induction of meetallothionin synthesis. Expand
Minimal role of metallothionein in decreased chelator efficacy for cadmium.
It appears that Metallothionein does not have an important role in the acute decrease in efficacy of chelation therapy for Cd poisoning, and the quick onset of chelator ineffectiveness may be due to the rapid uptake of Cd into tissues which makes it relatively unavailable of chelated. Expand