The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.

@article{Greenwald1999TheMO,
  title={The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.},
  author={Jason Greenwald and V Le and Scott L Butler and Frederic D. Bushman and Senyon Choe},
  journal={Biochemistry},
  year={1999},
  volume={38 28},
  pages={8892-8}
}
Replication of HIV-1 requires the covalent integration of the viral cDNA into the host chromosomal DNA directed by the virus-encoded integrase protein. Here we explore the importance of a protein surface loop near the integrase active site using protein engineering and X-ray crystallography. We have redetermined the structure of the integrase catalytic domain (residues 50-212) using an independent phase set at 1.7 A resolution. The structure extends helix alpha4 on its N-terminal side (residues… CONTINUE READING

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