The mobility and diffusion coefficient of potassium in giant axons from Sepia

@article{Hodgkin1953TheMA,
  title={The mobility and diffusion coefficient of potassium in giant axons from Sepia},
  author={Alan Lloyd Hodgkin and Richard Darwin Keynes},
  journal={The Journal of Physiology},
  year={1953},
  volume={119}
}
The object of the experiments described here is to measure the mobility and diffusion coefficient of the potassium ions inside the giant axons of Sepia officinalis. The principle of the method is to make a short length of axoplasm radioactive by allowing internal potassium to exchange with externally applied 42K in a restricted region. If a fibre which has been treated in this way is washed with sea water and placed in oil, most of the 42K remains in the axoplasm since the extracellular space… 
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Hodgkin & Keynes (1950, 1953), working with isolated nerve fibres from Sepia, were able to show that the diffusion constant and the mobility of the radioactive K ions they had introduced into the nerve were little, if at all, less than those of K ions in free solution.
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Results have been extended to cover a wider range of potassium concentrations using horse, ox and sheep red cells as experimental material and the relationship between potassium influx and efflux studied.
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Results of this study indicate that the intracellular transport of Na+ and the fast axonal transport are two independent processes.
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