The mniopetals, new inhibitors of reverse transcriptases from a Mniopetalum species (basidiomycetes). II. Structure elucidation.

@article{Velten1994TheMN,
  title={The mniopetals, new inhibitors of reverse transcriptases from a Mniopetalum species (basidiomycetes). II. Structure elucidation.},
  author={Robert Dr. Velten and D{\"o}rte Klostermeyer and Bert Steffan and Wolfgang Steglich and Andreas Kuschel and Timm Anke},
  journal={The Journal of antibiotics},
  year={1994},
  volume={47 9},
  pages={
          1017-24
        }
}
The structures of six new drimance sesquiterpenoids, mniopetals A-F, were elucidated by a combination of chemical and spectroscopic methods. The mniopetals are inhibitors of RNA-directed DNA-polymerases. 
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The mniopetals, new inhibitors of reverse transcriptases from a Mniopetalum species (Basidiomycetes). I. Producing organism, fermentation, isolation and biological activities.
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Six novel enzyme inhibitors of RNA-directed DNA-polymerases of human immunodeficiency-, avian myeloblastosis and murine leukemia viruses were isolated from fermentations of a canadian Mniopetalum species and exhibit antimicrobial and cytotoxic properties.
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The structure of kuehneromycin A was elucidated by spectroscopic methods and it is shown that this compound is a non-competitive inhibitor of avian myeloblastosis virus and moloney murine leukemia virus reverse transcriptases.
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