The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis.

  title={The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis.},
  author={Claire L Dobson and Alan J Warren and Richard Pannell and Alan Forster and Isabelle Lavenir and Javier Rodriguez Corral and Andrew J. H. Smith and Terence H Rabbitts},
  journal={The EMBO journal},
  volume={18 13},
The MLL gene from human chromosome 11q23 is involved in >30 different chromosomal translocations resulting in a plethora of different MLL fusion proteins. Each of these tends to associate with a specific leukaemia type, for example, MLL-AF9 is found mainly in acute myeloid leukaemia. We have studied the role of the Mll-AF9 gene fusion made in mouse embryonic stem cells by an homologous recombination knock-in. Acute leukaemias developed in heterozygous mice carrying this fusion as well as in… CONTINUE READING


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