The mixed serotonin receptor agonist psilocybin reduces threat-induced modulation of amygdala connectivity

  title={The mixed serotonin receptor agonist psilocybin reduces threat-induced modulation of amygdala connectivity},
  author={Rainer Kraehenmann and Andr{\'e} Schmidt and Karl J. Friston and Katrin H. Preller and Erich Seifritz and Franz X. Vollenweider},
  booktitle={NeuroImage: Clinical},
Stimulation of serotonergic neurotransmission by psilocybin has been shown to shift emotional biases away from negative towards positive stimuli. We have recently shown that reduced amygdala activity during threat processing might underlie psilocybin's effect on emotional processing. However, it is still not known whether psilocybin modulates bottom-up or top-down connectivity within the visual-limbic-prefrontal network underlying threat processing. We therefore analyzed our previous fMRI data… CONTINUE READING
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