The mitotic spindle: a self-made machine.

@article{Karsenti2001TheMS,
  title={The mitotic spindle: a self-made machine.},
  author={Eric Karsenti and Isabelle Vernos},
  journal={Science},
  year={2001},
  volume={294 5542},
  pages={543-7}
}
The mitotic spindle is a highly dynamic molecular machine composed of tubulin, motors, and other molecules. It assembles around the chromosomes and distributes the duplicated genome to the daughter cells during mitosis. The biochemical and physical principles that govern the assembly of this machine are still unclear. However, accumulated discoveries indicate that chromosomes play a key role. Apparently, they generate a local cytoplasmic state that supports the nucleation and growth of… CONTINUE READING
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