The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.

@article{Coolican1997TheMA,
  title={The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.},
  author={S A Coolican and Dr. S. Samuel and Daina Z. Ewton and F J McWade and James R. Florini},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 10},
  pages={
          6653-62
        }
}
It is well established that mitogens inhibit differentiation of skeletal muscle cells, but the insulin-like growth factors (IGFs), acting through a single receptor, stimulate both proliferation and differentiation of myoblasts. Although the IGF-I mitogenic signaling pathway has been extensively studied in other cell types, little is known about the signaling pathway leading to differentiation in skeletal muscle. By using specific inhibitors of the IGF signal transduction pathway, we have begun… CONTINUE READING
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