The mitogen-induced lysophospholipid:acyl-CoA acyltransferase (LAT) expression in human T-lymphocytes is diminished by hydrocortisone.

@article{Kerkhoff1997TheML,
  title={The mitogen-induced lysophospholipid:acyl-CoA acyltransferase (LAT) expression in human T-lymphocytes is diminished by hydrocortisone.},
  author={C van den Kerkhoff and Ladan Gehring and Kai Habben and Klaus Resch and Volkhard Kaever},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={237 3},
  pages={632-8}
}
One of the earliest changes observed in activated lymphocytes is the enhanced incorporation of unsaturated fatty acids into membrane phospholipids catalyzed by phospholipases and acyltransferases. This early membrane phospholipid remodeling has been shown to be independent from protein synthesis. We have investigated the oleic acid incorporation into phospholipids of activated T-lymphocytes within hours and present data that the sustained membrane phospholipid remodeling in activated T… CONTINUE READING