The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation.

@article{Severin2010TheMP,
  title={The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation.},
  author={Sylvie Severin and Cedric Ghevaert and Alexandra Mazharian},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2010},
  volume={8 1},
  pages={17-26}
}
Megakaryopoiesis is a process by which bone marrow progenitor cells develop into mature megakaryocytes (MKs), which in turn produce platelets required for normal hemostasis. The mitogen-activated protein kinases (MAPKs) family comprises four main groups of proteins: extracellular signal-related kinases (ERKs) (ERK1/2 or p44/p42), ERK5, p38MAPKs (alpha, beta, gamma, delta) and c-Jun amino-terminal kinases (JNKs) (JNK 1, 2, 3). These intracellular signaling pathways play a pivotal role in many… CONTINUE READING

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