The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation.

@article{Robitaille2005TheMP,
  title={The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation.},
  author={Hubert Robitaille and Roxanne Proulx and Karine Robitaille and Richard Blouin and Lucie Germain},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 13},
  pages={12732-41}
}
In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain ill defined. We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK), acts in the epidermis to promote the terminal… CONTINUE READING

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