The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes.

@article{Talarmin1999TheMP,
  title={The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes.},
  author={H{\'e}l{\`e}ne Talarmin and Claude Rescan and Sandrine Cariou and Denise Glaise and Giuliana Zanninelli and Marc Bilodeau and Pascal Loyer and Christiane Guguen-Guillouzo and Georges Baffet},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 9},
  pages={
          6003-11
        }
}
In this study, activation of the mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signalling pathway was analyzed in proliferating rat hepatocytes both in vivo after partial hepatectomy and in vitro following epidermal growth factor (EGF)-pyruvate stimulation. First, a biphasic MEK/ERK activation was evidenced in G(1) phase of hepatocytes from regenerating liver but not from sham-operated control animals. One occurred in early G(1) (30 min to 4 h), and… CONTINUE READING
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