The mitochondrion interfering compound NPC-26 exerts potent anti-pancreatic cancer cell activity in vitro and in vivo

@article{Dong2016TheMI,
  title={The mitochondrion interfering compound NPC-26 exerts potent anti-pancreatic cancer cell activity in vitro and in vivo},
  author={Yang-Yang Dong and Yi-Huang Zhuang and Wen-Jie Cai and Yan Liu and Wen-Bing Zou},
  journal={Tumor Biology},
  year={2016},
  volume={37},
  pages={15053-15063}
}
The development of novel anti-pancreatic cancer agents is extremely important. Here, we investigated the anti-pancreatic cancer activity by NPC-26, a novel mitochondrion interfering compound. We showed that NPC-26 was anti-proliferative and cytotoxic to human pancreatic cancer cells, possibly via inducing caspase-9-dependent cell apoptosis. Pharmacological inhibition or shRNA-mediated silence of caspase-9 attenuated NPC-26-induced pancreatic cancer cell death and apoptosis. Further, NPC-26… CONTINUE READING
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