The mitochondrion as Janus Bifrons

@article{Zorov2007TheMA,
  title={The mitochondrion as Janus Bifrons},
  author={D B Zorov and Nickolay K. Isaev and Egor Yu Plotnikov and Ljubava D. Zorova and Elena V. Stelmashook and A. K. Vasileva and Alexandra Alexandrovna Arkhangelskaya and T. G. Khrjapenkova},
  journal={Biochemistry (Moscow)},
  year={2007},
  volume={72},
  pages={1115-1126}
}
The signaling function of mitochondria is considered with a special emphasis on their role in the regulation of redox status of the cell, possibly determining a number of pathologies including cancer and aging. The review summarizes the transport role of mitochondria in energy supply to all cellular compartments (mitochondria as an electric cable in the cell), the role of mitochondria in plastic metabolism of the cell including synthesis of heme, steroids, iron-sulfur clusters, and reactive… Expand
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References

SHOWING 1-10 OF 296 REFERENCES
Mitochondria Revisited. Alternative Functions of Mitochondria
TLDR
This review explores the alternative functions of mitochondria inside the cell and reactive oxygen species modulate a number of non-destructive cellular activities. Expand
Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms.
  • V. Skulachev
  • Biology, Medicine
  • Molecular aspects of medicine
  • 1999
TLDR
It is hypothesized that septic shock, as well as the stress-induced brain and heart ischemic diseases and cancer, exemplify mechanisms of phenoptosis purifying population, community of organisms or kin from dangerous or useless individuals. Expand
Mitochondrial damage as a source of diseases and aging: a strategy of how to fight these.
  • D. Zorov
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 1996
TLDR
Problems such as cellular aging and mitochondrial diseases, are discussed in light of the relevance to the problem of oxidative stress, and the possible complex of measures to lower the harmful effect of oxygen are reviewed. Expand
Mitochondrial contact sites: their role in energy metabolism and apoptosis.
TLDR
This review focuses on the structure and function of protein complexes in mitochondrial contact sites and their regulatory role in the cellular bioenergetics, intra- and extra-mitochondrial Ca2+ levels, and release of apoptosis-inducing factors. Expand
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
TLDR
It is proposed that MOMP is dictated by an interaction between the cytosol and the OMM, and although proteins of the O MM may be important in the process, the ‘decision’ to undergo apoptosis originates within the cytOSol with no participation (in terms of yes, no and when) by mitochondria. Expand
Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide‐producing mitochondria and cell
TLDR
It is proposed that ROS‐induced pore opening lowers ROS production due to maximal stimulation of mitochondrial O2 consumption and, hence, intracellular [O2] lowering and (b) complete dissipation of mitochondrial membrane potentials and, as a consequence, maximal oxidation of such respiratory chain carriers as CoQ. Expand
Molecular mechanism of ‘mitocan’‐induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl‐2 family proteins
TLDR
This model may provide a general mechanism for the action of inducers of apoptosis and anticancer drugs, mitocans, targeting mitochondria via ROS production. Expand
Reactive oxygen and nitrogen species: Friends or foes?
TLDR
The critical role of ROS in destructive processes under ischemia/reoxygenation and ischemic preconditioning is discussed, resulting in excessive “ROS induced ROS release”. Expand
On the Role of VDAC in Apoptosis: Fact and Fiction
TLDR
This review is an effort to shed light on the situation and identify reliable information from more questionable claims on VDAC and its many apparent conflicts and contradictions. Expand
A role for actin in aging and apoptosis.
TLDR
A role for actin in cell death and in promoting longevity of the budding yeast, Saccharomyces cerevisiae is identified and pathways which couple changes in actin dynamics to cell death are identified. Expand
...
1
2
3
4
5
...