The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway.

@article{Rauthan2013TheMU,
  title={The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway.},
  author={Manish Rauthan and Parmida Ranji and Nataly Aguilera Pradenas and Christophe Pitot and Marc Pilon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 15},
  pages={5981-6}
}
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme in the synthesis of cholesterol via the mevalonate pathway. This pathway also produces coenzyme Q (a component of the respiratory chain), dolichols (important for protein glycosylation), and isoprenoids (lipid moieties responsible for the membrane association of small GTPases). We previously showed that the nematode Caenorhabditis elegans is useful to study the… CONTINUE READING
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