The mitochondrial unfolded protein response—synchronizing genomes.

@article{Jovaisaite2015TheMU,
  title={The mitochondrial unfolded protein response—synchronizing genomes.},
  author={Virginija Jovaisaite and Johan Auwerx},
  journal={Current opinion in cell biology},
  year={2015},
  volume={33},
  pages={74-81}
}
Maintenance of the mitochondrial proteome is performed primarily by chaperones, which fold and assemble proteins, and by proteases, which degrade excess damaged proteins. Upon various types of mitochondrial stress, triggered genetically or pharmacologically, dysfunction of the proteome is sensed and communicated to the nucleus, where an extensive transcriptional program, aimed to repair the damage, is activated. This feedback loop, termed the mitochondrial unfolded protein response (UPR(mt… CONTINUE READING
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