The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures.

@article{Kaufman2007TheMT,
  title={The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures.},
  author={Brett A. Kaufman and Nela Durisic and Jeffrey M. Mativetsky and Santiago Costantino and Mark S. Hancock and P. Grutter and Eric A Shoubridge},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 9},
  pages={
          3225-36
        }
}
Packaging DNA into condensed structures is integral to the transmission of genomes. The mammalian mitochondrial genome (mtDNA) is a high copy, maternally inherited genome in which mutations cause a variety of multisystem disorders. In all eukaryotic cells, multiple mtDNAs are packaged with protein into spheroid bodies called nucleoids, which are the fundamental units of mtDNA segregation. The mechanism of nucleoid formation, however, remains unknown. Here, we show that the mitochondrial… CONTINUE READING
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