The mitochondrial transcription factor A functions in mitochondrial base excision repair.

  title={The mitochondrial transcription factor A functions in mitochondrial base excision repair.},
  author={Chandrika Canugovi and Scott Maynard and Anne-C{\'e}cile V. Bayne and Peter Sykora and Jingyan Tian and Nadja Cristhina de Souza-Pinto and Deborah L. Croteau and Vilhelm A. Bohr},
  journal={DNA repair},
  volume={9 10},
Mitochondrial transcription factor A (TFAM) is an essential component of mitochondrial nucleoids. TFAM plays an important role in mitochondrial transcription and replication. TFAM has been previously reported to inhibit nucleotide excision repair (NER) in vitro but NER has not yet been detected in mitochondria, whereas base excision repair (BER) has been comprehensively characterized in these organelles. The BER proteins are associated with the inner membrane in mitochondria and thus with the… CONTINUE READING


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