The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology.

@article{Lenaz2001TheMP,
  title={The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology.},
  author={Giorgio Lenaz},
  journal={IUBMB life},
  year={2001},
  volume={52 3-5},
  pages={159-64}
}
Mitochondria are major sources of reactive oxygen species (ROS); the main sites of superoxide radical production in the respiratory chain are Complexes III and I; however, other mitochondrial enzymes, such as Complex II, glycerol-1-phosphate dehydrogenase, and dihydroorotate dehydrogenase, are also involved in production of ROS. ROS appear to be released both in the matrix and in the intermembrane space; however, their appearance outside the mitochondria may not be physiologically relevant. ROS… CONTINUE READING

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