The mitochondrial permeability transition pore.

  title={The mitochondrial permeability transition pore.},
  author={Martin Crompton and Sukaina Virji and Victoria Doyle and Nicholas W. Johnson and Joanna M Ward},
  journal={Biochemical Society symposium},
This chapter reviews recent advances in the identification of the structural elements of the permeability transition pore. The discovery that cyclosporin A (CsA) inhibits the pore proved instrumental. Various approaches indicate that CsA blocks the pore by binding to cyclophilin (CyP)-D. In particular, covalent labelling of CyP-D in situ by a photoactive CsA derivative has shown that pore ligands have the same effects on the degree to which CsA both blocks the pore and binds to CyP-D. The… CONTINUE READING
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