The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury.

@article{Trost1996TheMP,
  title={The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury.},
  author={Lawrence C. Trost and John J. Lemasters},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={278 3},
  pages={1000-5}
}
Aspirin, Neem oil, valproic, adipic, benzoic, isovaleric, 3-mercaptopropionic and 4-pentenoic acids are implicated in the pathogenesis of Reye's syndrome, Jamaican vomiting sickness, and related chemical toxicities. These disorders are characterized by hyperammonemia, hypoglycemia, microvesicular steatosis and encephalopathy. The goal of this study was to determine whether chemicals implicated in Reye's-related disorders induce the mitochondrial permeability translation (MPT). The MPT is… CONTINUE READING

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