The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis.

@article{Gilkerson2013TheMN,
  title={The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis.},
  author={Robert Gilkerson and Liliana Bravo and Iraselia Garcia and Norma Gaytan and Alan Herrera and Alicia Maldonado and Brandi Quintanilla},
  journal={Cold Spring Harbor perspectives in biology},
  year={2013},
  volume={5 5},
  pages={a011080}
}
The packaging of mitochondrial DNA (mtDNA) into DNA-protein assemblies called nucleoids provides an efficient segregating unit of mtDNA, coordinating mtDNA's involvement in cellular metabolism. From the early discovery of mtDNA as "extranuclear" genetic material, its organization into nucleoids and integration into both the mitochondrial organellar network and the cell at large via a variety of signal transduction pathways, mtDNA is a crucial component of the cell's homeostatic network. The… CONTINUE READING