The mitochondrial genome encodes abundant small noncoding RNAs

  title={The mitochondrial genome encodes abundant small noncoding RNAs},
  author={Seungil Ro and Hsiu-Yen Ma and Chanjae Park and Nicole Ortogero and Rui Song and Grant W. Hennig and Huili Zheng and Yung-Ming Lin and Loredana Moro and J Hsieh and Wei Yan},
  journal={Cell Research},
Small noncoding RNAs identified thus far are all encoded by the nuclear genome. Here, we report that the murine and human mitochondrial genomes encode thousands of small noncoding RNAs, which are predominantly derived from the sense transcripts of the mitochondrial genes (host genes), and we termed these small RNAs mitochondrial genome-encoded small RNAs (mitosRNAs). DICER inactivation affected, but did not completely abolish mitosRNA production. MitosRNAs appear to be products of currently… CONTINUE READING
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