The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis.

@article{Alirol2006TheMF,
  title={The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis.},
  author={Emilie Alirol and Dominic I. James and Denise Huber and Andrea Marchetto and Lodovica Vergani and J C Martinou and Luca Scorrano},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 11},
  pages={
          4593-605
        }
}
Mitochondrial fission ensures organelle inheritance during cell division and participates in apoptosis. The fission protein hFis1 triggers caspase-dependent cell death, by causing the release of cytochrome c from mitochondria. Here we show that mitochondrial fission induced by hFis1 is genetically distinct from apoptosis. In cells lacking the multidomain proapoptotic Bcl-2 family members Bax and Bak (DKO), hFis1 caused mitochondrial fragmentation but not organelle dysfunction and apoptosis… CONTINUE READING