The mitochondrial contact site complex, a determinant of mitochondrial architecture.

@article{Harner2011TheMC,
  title={The mitochondrial contact site complex, a determinant of mitochondrial architecture.},
  author={Max Emanuel Harner and Christian Koerner and Dirk Walther and Dejana Mokranjac and Johannes Kaesmacher and Ulrich Welsch and Janice Griffith and Matthias Mann and Fulvio Reggiori and Walter Neupert},
  journal={The EMBO journal},
  year={2011},
  volume={30 21},
  pages={
          4356-70
        }
}
Mitochondria are organelles with a complex architecture. They are bounded by an envelope consisting of the outer membrane and the inner boundary membrane (IBM). Narrow crista junctions (CJs) link the IBM to the cristae. OMs and IBMs are firmly connected by contact sites (CS). The molecular nature of the CS remained unknown. Using quantitative high-resolution mass spectrometry we identified a novel complex, the mitochondrial contact site (MICOS) complex, formed by a set of mitochondrial membrane… CONTINUE READING
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Mitochondria, 2nd edn

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