The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis

  title={The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis},
  author={Olga Catalina-Rodriguez and Vamsi Krishna Kolukula and York A. Tomita and Anju Preet and Ferdinando Palmieri and Anton Wellstein and Stephen W. Byers and Amato J. Giaccia and Eric Glasgow and Chris Albanese and Maria Avantaggiati},
Dysregulation of the pathways that preserve mitochondrial integrity hallmarks many human diseases including diabetes, neurodegeration, aging and cancer. The mitochondrial citrate transporter gene, SLC25A1 or CIC, maps on chromosome 22q11.21, a region amplified in some tumors and deleted in developmental disorders known as velo-cardio-facial- and DiGeorge syndromes. We report here that in tumor cells CIC maintains mitochondrial integrity and bioenergetics, protects from mitochondrial damage and… CONTINUE READING
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