The mitochondrial chaperonin hsp60 is required for its own assembly

@article{Cheng1990TheMC,
  title={The mitochondrial chaperonin hsp60 is required for its own assembly},
  author={Ming Yuan Cheng and F. Ulrich Hartl and Arthur L. Norwich},
  journal={Nature},
  year={1990},
  volume={348},
  pages={455-458}
}
HEATSHOCK protein 60 (hsp60) in the matrix of mitochondria is essential for the folding and assembly of newly imported proteins1. Hsp60 belongs to a class of structurally related chaperonins found in organelles of endosymbiotic origin and in the bacterial cytosol2–9. Hsp60 monomers form a complex arranged as two stacked 7-mer rings6. This 14-mer complex binds unfolded proteins at its surface, then seems to catalyse their folding in an ATP-dependent process10. The question arises as to how such… Expand
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