The mitochondrial carrier SLC25A10 regulates cancer cell growth

  title={The mitochondrial carrier SLC25A10 regulates cancer cell growth},
  author={Xiaoshan Zhou and Jo{\~a}o A. Paredes and Shuba Krishnan and Sophie Curbo and Anna Karlsson},
Dysregulation of cell metabolism is critical for the growth properties of cancer cells. The purpose of this study was to understand the role of substrate transport across the mitochondrial membrane to sustain the metabolic shift and redox defense in cancer cells. Mitochondrial carrier SLC25A10 is up-regulated in a variety of tumors and is involved in regulating intracellular levels of reactive oxygen species. We show that knockdown of SLC25A10 in A549 cells changed the growth properties to a… CONTINUE READING


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