The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells

  title={The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells},
  author={Liqin Cao and H. Shitara and T. Horii and Y. Nagao and H. Imai and K. Abe and T. Hara and J. Hayashi and H. Yonekawa},
  journal={Nature Genetics},
  • Liqin Cao, H. Shitara, +6 authors H. Yonekawa
  • Published 2007
  • Biology, Medicine
  • Nature Genetics
  • Observations of rapid shifts in mitochondrial DNA (mtDNA) variants between generations prompted the creation of the bottleneck theory. A prevalent hypothesis is that a massive reduction in mtDNA content during early oogenesis leads to the bottleneck. To test this, we estimated the mtDNA copy number in single germline cells and in single somatic cells of early embryos in mice. Primordial germ cells (PGCs) show consistent, moderate mtDNA copy numbers across developmental stages, whereas primary… CONTINUE READING
    265 Citations

    Figures, Tables, and Topics from this paper

    Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck.
    • 89
    • PDF
    Does mtDNA nucleoid organization impact aging?
    • 18
    Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them
    • 81
    • PDF
    What cost mitochondria? The maintenance of functional mitochondrial DNA within and across generations
    • 33
    • PDF
    Regular bottlenecks and restrictions to somatic fusion prevent the accumulation of mitochondrial defects in Neurospora
    • 20
    • PDF
    Variations in mouse mitochondrial DNA copy number from fertilization to birth are associated with oxidative stress.
    • 50


    Evidence from human oocytes for a genetic bottleneck in an mtDNA disease.
    • 140
    Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis.
    • 441
    • PDF
    Skewed segregation of the mtDNA nt 8993 (T-->G) mutation in human oocytes.
    • 168
    • PDF
    Organization and dynamics of human mitochondrial DNA
    • 354
    • PDF