The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells

@article{Cao2007TheMB,
  title={The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells},
  author={Liqin Cao and H. Shitara and T. Horii and Y. Nagao and H. Imai and K. Abe and T. Hara and J. Hayashi and H. Yonekawa},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={386-390}
}
  • Liqin Cao, H. Shitara, +6 authors H. Yonekawa
  • Published 2007
  • Biology, Medicine
  • Nature Genetics
  • Observations of rapid shifts in mitochondrial DNA (mtDNA) variants between generations prompted the creation of the bottleneck theory. A prevalent hypothesis is that a massive reduction in mtDNA content during early oogenesis leads to the bottleneck. To test this, we estimated the mtDNA copy number in single germline cells and in single somatic cells of early embryos in mice. Primordial germ cells (PGCs) show consistent, moderate mtDNA copy numbers across developmental stages, whereas primary… CONTINUE READING
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