The mitochondrial K(ATP) channel--fact or fiction?

  title={The mitochondrial K(ATP) channel--fact or fiction?},
  author={Keith D. Garlid and Andrew Philip Halestrap},
  journal={Journal of molecular and cellular cardiology},
  volume={52 3},
The mitochondrial ATP-dependent K(+) channel (mitoK(ATP)) is widely considered by many to play a central role in cardioprotection by ischemic and pharmacological preconditioning and by ischemic postconditioning. Nevertheless, several laboratories have questioned the existence of mitoK(ATP). This article summarizes the evidence for and against and addresses two key questions: How strong is the evidence for the presence of a K(ATP) channel in mitochondria? Are the pharmacological agents used to… CONTINUE READING
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