The mitochondrial DNA mutations associated with cardiac arrhythmia investigated in an LQTS family

@inproceedings{Khatami2014TheMD,
  title={The mitochondrial DNA mutations associated with cardiac arrhythmia investigated in an LQTS family},
  author={Fatemeh Khatami and Mohammad Mehdi Heidari and Massoud Houshmand},
  booktitle={Iranian journal of basic medical sciences},
  year={2014}
}
OBJECTIVES As mitochondrial oxidative stress is probably entailed in ATP production, a candidate modifier factor for the long QT syndrome (LQTS) could be mitochondrial DNA (mtDNA). It has been notified that ion channels' activities in cardiomyocytes are sensitive to the ATP level. MATERIALS AND METHODS The sample of the research was an Iranian family with LQTS for mutations by PCR-SSCP and DNA sequencing. The study searched about 40% of the entire mitochondrial genome in the family. RESULTS… CONTINUE READING