The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

@article{Wai2008TheMD,
  title={The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes},
  author={T. Wai and Daniella Teoli and E. Shoubridge},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={1484-1488}
}
  • T. Wai, Daniella Teoli, E. Shoubridge
  • Published 2008
  • Biology, Medicine
  • Nature Genetics
  • In mammals, mitochondrial DNA (mtDNA) sequence variants are observed to segregate rapidly between generations despite the high mtDNA copy number in the oocyte. [...] Key Method By directly tracking the evolution of mtDNA genotypic variance during oogenesis, we show that the genetic bottleneck occurs during postnatal folliculogenesis and not during embryonic oogenesis.Expand Abstract
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    References

    SHOWING 1-10 OF 32 REFERENCES
    Organization and dynamics of human mitochondrial DNA
    • 354
    • PDF
    Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA
    • 407
    • PDF
    Mitochondrial DNA copy number in bovine oocytes and somatic cells.
    • 196