The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

@article{Wai2008TheMD,
  title={The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes},
  author={Timothy Wai and Daniella Teoli and Eric A Shoubridge},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={1484-1488}
}
In mammals, mitochondrial DNA (mtDNA) sequence variants are observed to segregate rapidly between generations despite the high mtDNA copy number in the oocyte. [...] Key Method By directly tracking the evolution of mtDNA genotypic variance during oogenesis, we show that the genetic bottleneck occurs during postnatal folliculogenesis and not during embryonic oogenesis.Expand
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