The missing developmental dimension in the network perspective.

  title={The missing developmental dimension in the network perspective.},
  author={Sam V Wass and Annette Karmiloff-Smith},
  journal={The Behavioral and brain sciences},
  volume={33 2-3},
We welcome network theory as a tool for modelling the multi-directional interactions that characterise disease. However, we feel that Cramer et al. have neglected one important aspect: how diseases change over developmental time. We discuss principles such as fan in, fan out, bottlenecks, and common pathways, and argue that modelling these developmental aspects can be vital, particularly in deriving properly targeted treatments. 

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