The mismeasure of machine: Synthetic biology and the trouble with engineering metaphors.
@article{Boudry2013TheMO, title={The mismeasure of machine: Synthetic biology and the trouble with engineering metaphors.}, author={M. Boudry and M. Pigliucci}, journal={Studies in history and philosophy of biological and biomedical sciences}, year={2013}, volume={44 4 Pt B}, pages={ 660-8 } }
The scientific study of living organisms is permeated by machine and design metaphors. Genes are thought of as the "blueprint" of an organism, organisms are "reverse engineered" to discover their functionality, and living cells are compared to biochemical factories, complete with assembly lines, transport systems, messenger circuits, etc. Although the notion of design is indispensable to think about adaptations, and engineering analogies have considerable heuristic value (e.g., optimality… Expand
Topics from this paper
Paper Mentions
Blog Post
Blog Post
47 Citations
Machine metaphors and ethics in synthetic biology
- Sociology, Medicine
- Life sciences, society and policy
- 2018
- 6
- PDF
Evolutionary tinkering vs. rational engineering in the times of synthetic biology
- Medicine
- Life sciences, society and policy
- 2018
- 6
Is synthetic biology mechanical biology?
- Biology, Medicine
- History and philosophy of the life sciences
- 2015
- 4
Engineering and Biology: Counsel for a Continued Relationship
- Biology, Medicine
- Biological theory
- 2015
- 9
- PDF
Design Methodologies and the Limits of the Engineering-Dominated Conception of Synthetic Biology
- Computer Science, Medicine
- Acta biotheoretica
- 2019
- 1
- Highly Influenced
- PDF
How to do things with metaphors: engineering life as hodgepodge
- Sociology, Medicine
- Life sciences, society and policy
- 2018
- 1
Synthetic biology, metaphors and responsibility
- Sociology, Medicine
- Life sciences, society and policy
- 2017
- 24
References
SHOWING 1-10 OF 66 REFERENCES
Synthetic organisms and living machines
- Computer Science, Medicine
- Systems and Synthetic Biology
- 2009
- 47
- PDF
Synthetic biology: new engineering rules for an emerging discipline
- Biology, Medicine
- Molecular systems biology
- 2006
- 1,010
- PDF
Genotype–phenotype mapping and the end of the ‘genes as blueprint’ metaphor
- Biology, Medicine
- Philosophical Transactions of the Royal Society B: Biological Sciences
- 2010
- 194
- PDF
The Conception of Life in Synthetic Biology
- Sociology, Computer Science
- Sci. Eng. Ethics
- 2012
- 28
- Highly Influential
- PDF
The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme
- Biology, Medicine
- Proceedings of the Royal Society of London. Series B. Biological Sciences
- 1979
- 6,146
- PDF