The mismatch repair system is required for S-phase checkpoint activation

@article{Brown2003TheMR,
  title={The mismatch repair system is required for S-phase checkpoint activation},
  author={Kevin Brown and Abhilasha Vikas Rathi and Ravindra R. Kamath and Dillon I. Beardsley and Qimin Zhan and Jennifer L. Mannino and Rajasekaran Baskaran},
  journal={Nature Genetics},
  year={2003},
  volume={33},
  pages={80-84}
}
Defective S-phase checkpoint activation results in an inability to downregulate DNA replication following genotoxic insult such as exposure to ionizing radiation. This 'radioresistant DNA synthesis' (RDS) is a phenotypic hallmark of ataxia–telangiectasia, a cancer-prone disorder caused by mutations in ATM. The mismatch repair system principally corrects nucleotide mismatches that arise during replication. Here we show that the mismatch repair system is required for activation of the S-phase… CONTINUE READING
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