The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine.

  title={The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine.},
  author={Angen Liu and Ken-ichi Yoshioka and Vincenzo Salerno and Peggy Hsieh},
  journal={Journal of cellular biochemistry},
  volume={105 1},
The loss of DNA mismatch repair (MMR) is responsible for hereditary nonpolyposis colorectal cancer and a subset of sporadic tumors. Acquired resistance or tolerance to some anti-cancer drugs occurs when MMR function is impaired. 5-Fluorouracil (FU), an anti-cancer drug used in the treatment of advanced colorectal and other cancers, and its metabolites are incorporated into RNA and DNA and inhibit thymidylate synthase resulting in depletion of dTTP and incorporation in DNA of uracil. Although… CONTINUE READING
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